WebEthylene glycol is a clear, odorless, slightly viscous liquid with a sweet taste. It is combustible and has a low vapor pressure. Ethylene glycol is a very useful industrial compound because of its low freezing point and high boiling point. It is widely available as automotive antifreeze; in that application, it is often mixed with a yellow-green fluorescent. WebJun 13, 2005 · Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate.
Antifreeze poisoning: Symptoms, treatment, and prevention
WebNov 28, 2024 · If ethylene glycol poisoning is suspected, begin antidotal therapy empirically while awaiting confirmation. This is performed with either fomepizole (4-MP) or ethanol. … WebEthylene glycol poisoning. Ethylene glycol is a colorless, odorless, sweet-tasting chemical. It is poisonous if swallowed. Ethylene glycol may be swallowed accidentally, or it may be taken deliberately in a suicide attempt or as a substitute for drinking alcohol (ethanol). Most ethylene glycol poisonings occur due to the ingestion of antifreeze. rowsums df 3:4
Ethylene glycol as an efficient and reversible liquid …
Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include intoxication, vomiting and abdominal pain. Later symptoms may include a decreased level of consciousness, headache, and seizures. Long term outcomes may include kidney failure and brain damage. … See more Signs of ethylene glycol poisoning depend upon the time after ingestion. Symptoms usually follow a three-step progression, although poisoned individuals will not always develop each stage. • Stage … See more As many of the clinical signs and symptoms of ethylene glycol poisoning are nonspecific and occur in many poisonings the diagnosis is … See more Stabilization and decontamination The most important initial treatment for ethylene glycol poisoning is stabilizing the person. As … See more The most common source of ethylene glycol is automotive antifreeze or radiator coolant, where concentrations are high. Other sources of ethylene glycol include windshield deicing … See more The three main systems affected by ethylene glycol poisoning are the central nervous system, metabolic processes, and the See more Antifreeze products for automotive use containing propylene glycol in place of ethylene glycol are available, and are generally … See more Treatment for antifreeze poisoning needs to be started as soon after ingestion as possible to be effective; the earlier treatment is started, the greater the chance of survival. … See more WebNov 28, 2024 · Medication Summary. If ethylene glycol poisoning is suspected, begin antidotal therapy empirically while awaiting confirmation. Antidotes are fomepizole and … WebMar 18, 1999 · Ethylene glycol poisoning may cause severe morbidity and death. 1 Though not toxic itself, ethylene glycol is converted by alcohol … streserch